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Cantron and Protocel

Studies conducted by 2 independent laboratories demonstrate that Cantron is extremely effective antioxidant against health damaging free radicals. It is one of the most potent free radical scavengers ever tested, able to prevent or reverse serious health conditions. The phenolic content of Cantron was measured at an incredibly high 86,659.24 mg/L. Previously it was believed that OPC - a substance that comes from grape seeds and pine bark - was the world’s most powerful antioxidant supplement.  These studies show that Cantron  more effective than OPC and all other antioxidants in its ability to scavenge a wide range of the dangerous “Reactive Oxygen Species” or free radicals.

OPC is reported to be 20 times more effective than the vitamin C standard on water-soluble peroxyl radicals and 50 times more powerful than the vitamin E standard on fat-soluble peroxyl radicals (these standards were established by the US Department of Agriculture). Cantron is in a league of its own as is it up to 1769 times more powerful than the vitamin E and up to 424 times more powerful than the vitamin C. it is also 45 times more powerful than Gallic acid on hydroxyl radicals (the most reactive form of free radicals) and completely blocked the formation of superoxide radicals in the test system.  Cantron acts powerfully against a number of different free radicals that are responsible for multitudes of diseases in mankind.

On May 1, 2003, Brunswick completed a report on the ORAC levels of versions of Cantron. The New Millennium version of Cantron was 1,081,886 units and an experimental version was even more potent against peroxyl radicals scoring 1,135,591. A 1982 Entelev formula (manufactured by the original developer, James V. Sheridan) scored 879,050 in the ORAC test, a 1997 Cantron (Manufactured by Medical Research Products) scored 2,122,527, and a 1988 Cancell (manufactured by Edward Sopcak) product scored 1,882,618. The 1997 version of Cantron utilized the same manufacturing procedures as Ed Sopcak did in his Cancell formulation and was chemically identical. The 97 Cantron and 88 Cancell formulas worked significantly better on peroxyl radicals than the first samples, but rather surprisingly; they had almost no effect on hydroxyl radicals - the most dangerous radical of all. None of these 3 formulas were as effective as the Gallic Acid standard of 1,000 units. Entelev scored 161, 1997 Cantron scored 236 and 1988 Cancell scored 215 as compared to New Millennium Cantron’s 45,003.

Short History

In the 1930's, the biochemist, James Vincent Sheridan developed Entelev. This name was later changed to Cancell today is is called Cantron and Protocel. Cancell (Entelev), also known as Sheridan’s Formula, Jim’s Juice, Crocinic Acid, JS–114, JS–101, 126–F, and Cantron, is a liquid that has been distributed as a treatment for cancer and a wide range of other diseases.  Protocel comes in two froms, Protocel Formula 23 and the newer  Protocel Formula 50. Formula 50 is designed to aid the immune system in its unending effort to cleanse the body (i.e. it serves as an antioxidant). Cancell (Entelev) has been produced in various forms, principally by two manufacturers, since the late 1930’s.  The U.S. Food and Drug Administration (FDA) has listed the components of Cancell (Entelev) as the chemicals inositol, nitric acid, sodium sulfite, potassium hydroxide, sulfuric acid, and catechol.  However, the exact composition of Cancell is unknown.  Independent tests on one form of Cancell found 12 different compounds, none of which are known to be effective in treating any form of cancer.

Entelev and CanCell, the dark liquid versions were invented by Jim Sheridan and belonged to the Sheridan family. A Mr. Sopcak came up with a homeopathic version which he also called CanCell much to everyone's confusion and talked about them interchangeably, which, of course, caused a lot of difficulties. This is not considered the same formula or as effective. A number of people have managed to acquire pieces of Sheridan's and/or Sopcak's technology over the years. The most notable is a promoter named Jerome Godin (Medical Research Products).

In 1978 and 1980, the National Cancer Institute (NCI) conducted animal studies on Cancell, determining that the mixture lacked substantial anticancer activity.  Samples of Cancell were also tested under NCI’s In Vitro (laboratory) Anticancer Drug Discovery Program in 1990 and 1991.  On the basis of negative results from these studies, NCI researchers concluded that no further study of Cancell was warranted. The FDA has obtained an injunction forbidding its distribution to patients.

Entelev, the original name of the mixture, was assigned an IND (Investigational New Drug) number by the FDA in 1982.  This IND is inactive, because information about the product’s composition and studies showing its therapeutic effectiveness in animals have not been submitted to the FDA.  In 1989, the principal manufacturers of Entelev were permanently prohibited from distributing the mixture, which was judged to be an unapproved new drug by the FDA.  Therefore, Cancell (Entelev) is not approved for use in the United States.

Currently the original Entelev formula is held by two different companies.  The products of these two companies are Protocel and Cantron.  There are testimonials on the internet for each of these products.  Nevertheless, "Today, the Sheridan family endorses Protocel as THE Cancell formula." The two principal manufacturers of Cancell have offered different explanations for the development of cancer, but their theories about how the mixture works against cancer are similar.  According to the original manufacturer, Cancell changes cancer cells so they are seen by the body as “foreign” and are destroyed.  The second manufacturer states that Cancell changes cancer cells so they “self-digest” and are replaced by normal cells.  The waste material produced by this self-digestion process is eliminated through urine, perspiration, and other body fluids.

As an alternate medicine, proponents of Cantron state that the formulation:

"Cantron is a unique nutritional formulation containing vitamins, minerals and a proprietary blend of organic compounds.
Vitamins: trace amounts of the B vitamin Inositol.
Minerals: Copper, Sodium and Potassium.
Proprietary blend of organic compounds: Catechol (from Pyrocatechol) and the following Hydroxyquinones; Tetrahydroxyquinone, Rhodizonic Acid, Croconic Acid, Triquinol, Leuconic Acid.
The ingredients in Cantron are utilized for their bioelectrical properties (not their chemical properties), for their roles in cellular respiration and for their anti-oxidant properties." It is likely the proprietary compounds that are effective as antioxidants.

Administration of Cantron

Cantron can be administered by mouth (orally) or rectally, or it can be applied to the skin of the wrist or the ball of the foot.  Cancer patients have been advised to take bromelain, a digestive aid, and to avoid high intakes of vitamins C and E while using Cantron. The side effects associated with Cantron include temporary, sometimes moderate fatigue during the first few weeks of treatment.  Nausea is also a reported side effect.  One patient who exceeded the manufacturer’s dose recommendations experienced diarrhea for a few hours, but was reported to be fine the next day.

The daily dosage for Cantron is small (one and a half teaspoons).  Obviously, one is able to consume a great deal more orange juice than Cantron.  The prescribed daily dose of Cantron still provides significant antioxidant benefits.  To obtain equivalent peroxyl scavenging protection of a daily dose of Cantron, one would have to consume 44 ounces of orange juice (5 1/2 cups).  Orange juice is not effective upon hydroxyl or superoxide radicals. To get the equivalent protection of a daily dose of Cantron one would also have to consume 11/2 cups (12 oz.)  of green tea that contains at least 95% polyphenols and mega doses of superoxide dismutase and/or catalase. 


Recent test show Cantron to be an effective antioxidant and it may have benefits from this perspective. This complementary and alternative medicine (CAM) information summary provides an overview of the use of Cancell (Entelev, Cantron) as a treatment for cancer. This summary contains the following key information: 

  • Cancell/Entelev has been promoted by its manufacturers as an effective therapy for cancer and a number of other diseases.
  • Cancell/Entelev is a mixture of common chemicals, none of which is known to be effective in treating any type of cancer.
  • No animal study or human study of Cancell/Entelev has been published in a peer-reviewed, scientific journal to show that it is safe or effective in treating cancer.
  • Cancell/Entelev is not approved for use in the United States.


Always consult your doctor. This site is for information purposes and does not prescribe products. Confirm all details with a specialist (see disclaimer).

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